Well like you said, some people may not read that letter just because it is not from a neurosurgeon. However, someone that has known you for six years should be able to give you a much better letter than someone who has seen you for part of one month. It’s definitely a plus that he’s a spine guy as well. Also, some people may wonder why you wouldn’t give them a letter from someone who you have worked with for so long. I would make sure that my other 3 letters are very strong ie. from program directors/chairmen of neurosurgery programs that agree to write you a strong letter. My research mentor wasn’t well known at all and I still used his letter because he had seen my work for 2 years. Even though my guy was a neurosurgeon I was still wrestling with the same type of question. But at the end of the day when I weighed my ups and downs I thought it would be good to have a letter from someone that got to know me pretty well.